The idyllic picture of Meredith and Derek's future begins to fray as they discover their contentment is far from assured. Amidst this shift, Cristina finds herself drawn to a military doctor who arrives with a critical trauma case. Elsewher…

Alex felt a sharp sting of displeasure when Izzie spoke of his merits to Meredith. Meanwhile, Derek received a wound – a scalpel’s cruel kiss to the palm of his hand, inflicted by Rose. The Chief, preoccupied, wrestled with the escalating p…

A burst pipe throws Seattle Grace into disarray as the Chief attempts to implement innovative teaching strategies. Simultaneously, George faces his residency examination, while Derek endeavors to persuade Meredith’s roommates to vacate the …

The discovery of her mother’s diary throws Meredith into a disquieting turmoil when Derek finds it within the house. Elsewhere, Callie wrestles with nerves as she prepares for her inaugural date with Erica. And later still, Cristina inadver…

Bailey orchestrates a delicate sequence of surgeries, each dependent on the success of the last. Simultaneously, Derek claims full credit for the brain tumor study he conducted with Meredith; Lexie attempts to capture George's romantic atte…

The chief bestows upon Bailey increased authority and a greater measure of responsibility. He also assigns her a particularly challenging surgical case: the removal of a tumor deemed previously inoperable in a young girl. Simultaneously, th…

The Chief's announcement of a coveted solo surgery sparked a competitive fervor among the residents, each vying for the opportunity. Separately, Derek sought counsel from Bailey, troubled by Cristina’s persistent meddling in his relationshi…

Sadie, a friend of Meredith’s from long ago, secured an internship at Seattle Grace, though Meredith's circle of friends greeted her arrival with a cool reserve.

When a routine surgery takes a disastrous turn, Meredith, Cristina, and Bailey rush to help Lexie and Sadie. Meanwhile, Owen and Derek attend to a man gravely wounded during a sleepwalking episode, while Mark offers solace to the sleepwalke…

Cristina earned the distinction of performing the first solo surgery among the residents, only to find herself compelled to relinquish the opportunity and select her successor. Lexie was struck by the advanced nature of the procedure Mark u…

Bailey finds an unexpected ally in Dr. Arizona Robbins, Seattle Grace’s newest pediatric surgeon, as they race against time to save a young patient deeply important to Bailey. The arrival of a death row inmate at the hospital ignites Derek’…

Carolyn, Derek’s mother, arrives unexpectedly in Seattle and encounters Meredith for the first time, a delicate situation complicated by Mark's efforts to keep his relationship with Lexie a secret. Elsewhere, William, an inmate awaiting exe…

As the patient’s condition deteriorates, Bailey feels a growing sense of desperation. The entire hospital staff rallies, striving to locate a compatible organ donor for the boy. Meredith wrestles with the ethical complexities of honoring a …

With the engagement ring now in his possession, Derek sought the ideal moment to propose to Meredith. Meanwhile, Lexie pressed Mark to publicly acknowledge their relationship, and Bailey, emboldened by recent cases and counsel from Dr. Dixo…

Naomi Addison, along with Naomi and Sam, hurried the stricken Archer to Seattle Grace, where they found themselves reunited with Derek and Mark, ready to join the effort to save his life. Simultaneously, Izzie orchestrated a medical exerci…

Derek’s self-assurance is fractured as he confronts Addison regarding the optimal treatment for their failing pregnant patient. Cristina questions the skill of a celebrated surgeon after a routine procedure goes awry. Meanwhile, Bailey, hav…

The revelation that more of his patients had succumbed than recovered proved a breaking point for Derek. Meanwhile, a disquieting discovery regarding "Patient X" unfolded among Izzie’s interns.

Following the unsuccessful attempts of his colleagues to persuade Derek to return to the operating room, Meredith must find the resolve to do so herself. The hospital hums with anticipation as Mark undertakes a rare face transplant. Cristin…

Derek stood as the center of attention, poised to perform his first surgery since his breakdown. Meanwhile, Izzie faced a daunting operation necessary to address her own medical crisis. Adding to the turmoil, Owen experienced another episod…

Battling the relentless progression of her cancer, Izzie found solace in meticulously organizing the details of Derek and Meredith’s wedding.

With the wedding of Meredith and Derek drawing nearer, Izzie finds herself unexpectedly visited by her demanding mother, Robbie. Elsewhere, Thatcher, now sober, seeks out his daughters, Meredith and Lexie, hoping for a chance to atone. Simu…

Amidst the flurry of preparations for Meredith and Derek's wedding, a group of college students, victims of a severe car accident on their way to graduation, are brought to the emergency room. Simultaneously, Izzie finds herself gripped by …

The season finale's opening hour finds Izzie connecting with another patient navigating the complexities of cancer treatment. She grapples with a difficult decision: whether to risk a potentially perilous surgery. Meanwhile, Mark prepares t…

The final hour of the season's two-part conclusion sees George delivering startling news to Bailey, a revelation that reverberates through the hospital. Elsewhere, Izzie’s friends await word on her recovery from surgery with anxious hearts.…