A strange illness fell upon Ichika's young daughter, and she implored Yasuke to take them upriver to a physician known for his skill. But Yasuke refused her request.

In 1581, Yasuke and Natsumaru had earned the unwavering trust of Nobunaga, serving as his loyal warriors. Years later, the mercenaries finally located them and launched a surprise attack.

Abraham dispatched Haruto and Nikita to locate Saki, who met their arrival with a surge of burgeoning power, turning the tide in her favor. Meanwhile, under duress, Yasuke was seized by a vivid memory of treachery.

Returning to the village, Saki insisted that Yasuke take her to Doctor Morisuke, refusing any argument. Yet, they were not unobserved; new adversaries were now on their trail.

As the Daimyo's assault breached the Astral Plane, Morisuke shielded Saki from the onslaught. Meanwhile, Yasuke faced the masked Dark General, who then unveiled their true self.

As Morisuke and his warriors established a defensive perimeter around the temple, Yasuke and Saki confronted the Daimyo within the walls of Azuchi Castle.