In Penamstan, while working for an NGO, Claire notices unsettling echoes of Raccoon City. Meanwhile, Leon journeys toward the White House, oblivious to the assault that awaits him there.

Leon, accompanied by agents Jason and Shen May, undertakes a clandestine mission: to penetrate a research facility within Shanghai, utilizing a nuclear submarine as their vessel.

At the residence of a lone survivor from the Mad Dogs Unit, Claire found a disturbing tableau. Shen May cautioned Leon about a sinister conspiracy unfolding around them.

Secretary Wilson issued a veiled threat against Claire, a chilling demand for her to abandon her inquiry. Meanwhile, Leon and Shen May hurried toward the immense, hidden laboratory where bioweapons were developed.