Kirkman, a newcomer to the political arena, and his fledgling campaign begin their efforts with a hesitant start. Meanwhile, Wells receives an important new assignment.

Discord over child marriage has stirred deep within Kirkman’s ranks. For Mars, the grip of opioid addiction is a personal affliction. And a biohacker reveals to Wells a disturbing, unforeseen danger.

A political assault on Kirkman has thrust issues of privacy and transgender rights into sharp focus. Meanwhile, Aaron grapples with a weighty choice. Elsewhere, Wells and Eli pursue a bioterrorist.

The complexities of Aaron’s ancestry and a city-wide teachers' strike ignited deep divisions within the community. Meanwhile, Wells began to discern a disturbing pattern emerging from the recent flu outbreak, hinting at something far more s…

A surge of feeling followed the rapid spread of malicious falsehoods. Isabel ignited debate with a provocative plea, while Wells discovered a sign pointing towards a deeper plot.

The fragile life of a Guatemalan child, fading within a Texas hospital, casts a sharp light on the complexities of immigration. For Kirkman, a sudden mugging in the city's heart serves as a brutal awakening to the harsh realities of existe…

A lone Russian bomber threatens Seattle, Mars wages war against a pharmaceutical giant, and a memory from Aaron’s youth troubles Kirkman's political efforts.

Kirkman launches a desperate pursuit of the bioterrorist. Meanwhile, Lorraine adopts a forceful approach, bringing the opioid crisis into the heart of the political struggle.

With the polls showing a significant deficit, Kirkman contemplates compelling the FBI to intervene in the bioterrorism plot. Meanwhile, Emily grapples with the complexities of her mother’s last desires.

Election day finds Kirkman seeking solace from his therapist, grappling with the weight of the past thirty-six hours – a period marked by significant events and difficult choices. He hopes to find some measure of peace regarding his conscie…